Intracellular pathogens including bacteria, viruses and protozoa hijack host cell functions to access nutrients and to bypass cellular defenses and immune responses.These strategies have been acquired through selective pressure and allowed pathogens to reach an appropriate cellular niche for their survival and growth.To get new insights on how para
Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy
Abstract Background Chemoradiotherapy (CRT) remains one of the most common cancer treatment modalities, and recent data suggest that CRT is maximally effective when there is generation of an anti-tumoral immune response.However, CRT Hair Extensions has also been shown to promote immunosuppressive mechanisms which must be blocked or reversed to maxi
Functional and technological prerequisites for architectural and space-planning design of test centers for technical systems
Ensuring the reliability and safety of technical systems is a milestone in their development and mass production.Reliability testing of technical systems is performed in special laboratories and centers.Today, there is a great deal of experience in simulating operating Pen Case conditions of technical systems in order to predict and increase their